Luke Slind

Human cytomegalovirus microRNAs target the Wnt signaling protein Dishevelled 3 to promote efficient reactivation in CD34+ hematopoietic progenitor cells

This study shows that HCMV miRNAs miR-US5-2 and miR-US25-2 downregulate Dvl3 during latency to enable efficient reactivation in CD34+ HPCs.

The human cytomegalovirus chemokine binding protein UL22A is necessary for efficient reactivation from latency in CD34+ hematopoietic progenitor cells.

This paper shows that HCMV's UL22A protein is essential for reactivation from latency in CD34+ hematopoietic progenitor cells, with tyrosine residues critical for this process, but RANTES neutralization does not fully restore reactivation.

HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36

This study shows HCMV uses UL8 and miR-UL36 to suppress Notch signaling, promoting reactivation in CD34+ hematopoietic progenitor cells.

Human Cytomegalovirus UL78 is a Nuclear-Localized GPCR Necessary for Efficient Reactivation from Latent Infection in CD34+ Hematopoietic Progenitor Cells

This study identifies UL78 as a nuclear-localized GPCR essential for HCMV reactivation from latency in CD34+ HPCs, showing its Gi coupling and interactome involvement in nuclear processes.

Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice

This study shows that HCMV miRNAs downregulate Akt to promote reactivation from latency in CD34+ cells and humanized mice.