Yan Chen

Human cytomegalovirus microRNAs target the Wnt signaling protein Dishevelled 3 to promote efficient reactivation in CD34+ hematopoietic progenitor cells

This study shows that HCMV miRNAs miR-US5-2 and miR-US25-2 downregulate Dvl3 during latency to enable efficient reactivation in CD34+ HPCs.

Therapeutic Potential of iPSC-Derived TH+FOXA2+ Neuronal Extracellular Vesicles in Parkinson's Disease Revealed by Organoid and Rodent Models

This study evaluates the therapeutic potential of iPSC-derived TH+FOXA2+ neuronal extracellular vesicles in Parkinson's disease models, showing neuroprotection and safety.

Hidden genetic diversity in 320 nearly-complete East Asian genome assemblies

The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.

PTH-Induced Behavioral and Metabolic Alterations in Mouse Models of Hyperparathyroidism

This study examines the behavioral and metabolic effects of PTH in mouse models of hyperparathyroidism, finding sex-specific behavioral changes and metabolic alterations.

IgG4⁺ plasma cell enrichment and {lambda}-chain-biased BCR remodeling drive low-grade autoimmunity in chronic obstructive pulmonary disease

This study identifies IgG4⁺ plasma cell enrichment and λ-chain-biased BCR remodeling in COPD, linking them to low-grade autoimmunity and chronic inflammation.

Mouse behavioral genomics identifies Creld1 as a gatekeeper of somatosensation

The paper identifies Creld1 as a master regulator of somatosensation through postnatal CRISPR screening and behavioral assays in mice.

Genome-wide cross-trait analysis of vascular dementia and Alzheimer's disease highlights novel loci and lung-brain axis

This study identifies novel genetic loci for vascular dementia and its association with lung function, and finds shared genetic risk factors with Alzheimer's disease.

Contrasting effects of glutamate and branched-chain amino acid metabolism on acid tolerance in a Castellaniella isolate from acidic groundwater

This study identifies glutamate and branched-chain amino acid metabolism as key factors in acid tolerance of a denitrifying bacterium from acidic groundwater.

Spliformer-V2 enables multi-tissue prediction and interpretation of splice-altering genetic variants

Spliformer-V2 predicts and interprets tissue-specific effects of splice-altering variants, identifying disease-relevant genes and therapeutic targets in ALS.

GeneCompass: Deciphering Universal Gene Regulatory Mechanisms with Knowledge-Informed Cross-Species Foundation Model

GeneCompass is a cross-species foundation model pre-trained on single-cell transcriptomes from human and mouse, integrating biological knowledge to improve gene regulatory mechanism understanding and downstream tasks.

Functional plasticity of HCO3- uptake and CO2 fixation in Cupriavidus necator H16

This study investigates the functional plasticity of HCO3- uptake and CO2 fixation in C. necator H16 by testing endogenous and heterologous genes, showing that DIC transporters can support autotrophic growth and higher cell densities.

Structure and Mechanism of a Structural and Functional Insights into the Action Mode of A Mitochondrial AAA+ DisaggregaseCLPB

This study reveals the structural and functional mechanism of CLPB, a mitochondrial AAA+ disaggregase, showing its unique assembly and substrate translocation properties.

Circulating proteins reveal prior use of menopausal hormonal therapy and increased risk of breast cancer

The paper identifies a proteomic signature associated with menopausal hormonal therapy use and increased breast cancer risk using a data-driven analysis of plasma proteins.