Divergent roles of SOX2 in human and mouse germ cell specification related to X-linked gene dosage effects
Wenteng He, Qing Luo, Jian Zhao, Mengting Wang, Allan Z. Zhao, Luohua Feng, Ahmed Reda, Eva Lindgren, Jan‐Bernd Stukenborg, Jiayu Chen, Qiaolin Deng
This study identifies how X-linked gene dosage affects human primordial germ cell-like cell (hPGCLC) specification, revealing species-specific roles of SOX2 and SOX17 influenced by escape genes.
Advanced Science · Feb 25, 2025Peer-reviewedCell Biology