Spatial multi-omics unveils the monoclonal origin, neuroendocrine plasticity, and microenvironment niches in combined small cell lung cancer
Zhuo Wang, Qing Luo, Jie Wu, Li Lu, Wenjie Ding, Yichun Zhao, Yongfeng YU, Ruoran Qiu, Ling Zhu, Xinxing Ouyang, Wendi Xuzhang, Shun Lu, Wei Wei, Qihui Shi, Ziming Li
This study uses spatial multi-omics to show cSCLC has a monoclonal origin, lineage plasticity, and distinct microenvironment niches, leading to a new diagnostic assay.
Cell Reports Medicine · Apr 1, 2026Peer-reviewedCancer Biology