HIV-1 resistance to islatravir/tenofovir combination therapy in wild-type or NRTI resistant strains of diverse HIV-1 subtypes
M. A. Cilento, X. Wen, A. B. Reeve, A. Snyder, O. Ukah, C. M. Carrillo, C. P. Smith, K. Edwards, C. C. Wahoski, D. R. Kitzler, E. N. Kodama, H. Mitsuya, M. Parniak, P. R. Tedbury, S. G. Sarafianos
This study evaluates resistance to islatravir and tenofovir in HIV-1 strains with mutations K65R, M184V, and S68G/N, showing that their combination has a high genetic barrier to resistance.
bioRxiv · Jun 18, 2023 · PreprintMicrobiology