Author

M. Alcalde

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein design· 2 Assay:protein sequence· 2 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

S. Barber-Zucker· 2 shared S. J. Fleishman· 2 shared E. Garcia-Ruiz· 1 shared I. Mateljak· 1 shared J. J. Weinstein· 1 shared J. M. Sanchez-Ruiz· 1 shared L. I. Gutierrez-Rus· 1 shared M. Goldsmith· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

S. Barber-Zucker

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Efficient base-catalysed Kemp elimination in an engineered ancestral enzyme

L. I. Gutierrez-Rus, M. Alcalde, V. A. Risso, J. M. Sanchez-Ruiz

This study engineers an ancestral β-lactamase to efficiently catalyze Kemp elimination, achieving catalytic parameters comparable to modern enzymes.

bioRxiv · Jul 28, 2022 · PreprintBiophysics

Designed high-redox potential laccases exhibit high functional diversity

S. Barber-Zucker, I. Mateljak, M. Goldsmith, M. Kupervaser, M. Alcalde, S. J. Fleishman

The paper designs high-redox potential laccases with improved stability and functional diversity through stabilization and active-site engineering.

bioRxiv · Jun 22, 2022Biochemistry

Stable and functionally diverse versatile peroxidases by computational design directly from sequence

S. Barber-Zucker, V. Mindel, E. Garcia-Ruiz, J. J. Weinstein, M. Alcalde, S. J. Fleishman

The paper designs stable and functionally diverse versatile peroxidases using computational methods, showing improved expression and environmental tolerance compared to wild-type enzymes.

bioRxiv · Nov 25, 2021 · PreprintBiochemistry