Connexin 46 and connexin 50 gap junction channel open stability and unitary conductance are shaped by structural and dynamic features of their N-terminal domains
B. Yue, B. G. Haddad, U. Khan, H. Chen, M. Atalla, Z. Zhang, D. M. Zuckerman, S. L. Reichow, D. Bai
This study investigates how structural and dynamic features of the N-terminal domains of connexin 46 and 50 influence gap junction channel stability and conductance through molecular dynamics simulations and electrophysiology.
bioRxiv · Jul 1, 2020Biophysics