H. Chen

Joint Learning of Drug-Drug Combination and Drug-DrugInteraction via Coupled Tensor-Tensor Factorization with SideInformation

This paper proposes a joint learning framework for predicting drug combinations and drug-drug interactions using coupled tensor-tensor factorization with side information, achieving strong performance on new-drug prediction.

Transcriptional and spatial profiling of fibroblasts from human lungs highlights CTHRC1+ cells as fibrogenic signaling hubs in fibrosis

The paper integrates single-cell RNA sequencing and spatial transcriptomics to identify CTHRC1+ fibroblasts as key fibrogenic cells in IPF, showing how culture affects their transcriptional profile.

Parallelized Droplet Vitrification Enables Single-Run Vitrification of the Whole Rat Liver Hepatocyte Yield

This paper introduces a parallelized droplet vitrification technique for rapid, high-volume cryopreservation of rat hepatocytes, achieving higher yield and faster droplet generation with improved post-preservation viability.

Phosphorylation-Dependent Activation of the bHLH Transcription Factor ICE1/SCRM Promotes Polarization of the Arabidopsis Zygote

This study shows that phosphorylation of the bHLH transcription factor SCRM by MPK3/6 promotes zygote polarization in Arabidopsis, contrasting with its role in epidermal cell divisions.

Dissecting cell-free DNA fragmentation variation in tumors using cell line-derived xenograft mouse

The paper investigates cfDNA fragmentation patterns in tumor models to distinguish between non-tumor cfDNA and ctDNA, finding differences in fragment length and site-specific variation.

Memantine Inhibits Calcium-Permeable AMPA Receptors

This study shows memantine inhibits calcium-permeable AMPA receptors, revealing a new mechanism distinct from NMDA receptors and suggesting therapeutic potential for neurological disorders.

An AINTEGUMENTA phospho-switch controls bilateral stem cell activity during secondary growth

This paper identifies a phosphorylation mechanism controlled by the ERECTA receptor and auxin signaling that regulates stem cell activity and vascular cell differentiation in plants.

A vacuolar invertase gene SlVI modulates sugar metabolism and postharvest fruit quality and resistance in tomato

This study investigates the role of the tomato vacuolar invertase gene SlVI in sugar metabolism, fruit quality, and postharvest resistance, finding that its knockout increases sucrose content, firmness, and resistance to Botrytis cinerea.

Digital pathology assessment of kidney glomerular filtration barrier ultrastructure in an animal model of podocytopathy

This paper develops a deep learning method to automate measurement of glomerular basement membrane and podocyte foot process widths in TEM images of podocytopathy mouse models, showing comparable accuracy to manual methods.

Fe3O4 nanoparticles shell amplify charge-extraction efficiency in Dunaliella photovoltaics

This study enhances Dunaliella-based microbial biophotovoltaics by coating them with Fe3O4 nanoparticles, improving electron transfer efficiency and power output.

c-di-GMP modulates ribosome assembly by inhibiting rRNA methylation

This study shows c-di-GMP inhibits rRNA methylation by binding to RlmI, modulates ribosome assembly, and promotes antibiotic tolerance in E. coli.

The genetic architecture of floral trait divergence between hummingbird- and self-pollinated monkeyflower (Mimulus) species

This study maps QTLs for floral traits in Mimulus species to reveal a polygenic and modular genetic architecture underlying pollination syndrome divergence.

Contracted anterior-posterior systematic covariance of cortical thickness in early-onset schizophrenia

This study identifies a contracted anterior-posterior organizational axis of cortical thickness in early-onset schizophrenia using structural MRI data.

Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer

This study evaluates the biological activity of 60c, a next-generation colchicine-binding site inhibitor, showing improved potency and anti-metastatic effects in triple-negative breast cancer models.

Autophagy suppression in DNA damaged cells occurs through a newly identified p53-proteasome-LC3 axis

The paper identifies a p53-proteasome-LC3 axis that suppresses autophagy in DNA damaged cells, linking p53 stabilization to reduced LC3A/B levels.

Clostridium ablates tumors by degrading collagen mesh andinducing ferroptosis

This paper describes a Clostridium strain that degrades collagen and induces ferroptosis in tumors, leading to effective tumor destruction in mice.

Persistent lung inflammation and alveolar-bronchiolization due to Notch signaling dysregulation in SARS-CoV-2 infected hamster

This study shows SARS-CoV-2 infection in hamsters causes persistent lung inflammation and alveolar-bronchiolization linked to Notch signaling dysregulation and potential cancer risk.

SLC13A2-transported citrate is a metabolic signal for PKM2 acetylation and degradation to suppress tumor growth

This paper identifies SLC13A2-transported citrate as a metabolic signal that promotes PKM2 acetylation and degradation, thereby suppressing tumor growth in hepatocellular carcinoma.

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model

The paper investigates how exercise affects Alzheimer's disease in mice by analyzing gene expression and chromatin changes, finding that growth factor signaling pathways are key to exercise's benefits.

Exogenous myristate fuels the growth of symbiotic arbuscular mycorrhizal fungi but disrupts their carbon-phosphorus exchange with host plants

This study shows that exogenous myristate supports AMF growth but reduces phosphorus transfer to host plants, suggesting it may hinder symbiosis.

A step-emulsion based digital-RPA for Pathogenic bacteria detection

This paper develops a step-emulsion microfluidic device combined with digital-RPA for rapid, sensitive, and quantitative detection of Vibrio parahaemolyticus with a detection limit of 10 CFU/L.

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19

The paper identifies a potent orally bioavailable SARS-CoV-2 PLpro inhibitor with in vitro and in vivo antiviral activity against SARS-CoV-2 and related coronaviruses.

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

This study shows that Piezo1 in intestinal L cells mechanically regulates GLP-1 production, affecting glucose tolerance and diabetes.

The structure and diversity of the bacterial community in the overlying water of the Yangzong Lake in Yunnan

This study analyzes bacterial community structure and diversity in Yangzong Lake overlying water using high-throughput sequencing, finding variations in physicochemical factors and dominant taxa across sampling sites.

WWP2 MEDIATES THE METABOLIC REPROGRAMMING OF RENAL MYOFIBROBLASTS TO PROMOTE KIDNEY FIBROSIS

This paper identifies WWP2 as a regulator of myofibroblast metabolic reprogramming in renal fibrosis, showing it suppresses PGC-1 to alter metabolic pathways and reduce fibrosis severity.

Tree growth is better explained by absorptive fine root traits than by transport fine root traits

This study compares absorptive and transport fine root traits in 25 European tree species and finds that absorptive root traits better explain tree growth than transport root traits.

A Comparative Study on the Superiority of AOS DP3-7 Over 5-ALA in Facilitating Pigment Change in Peppers

This study compares AOS DP3-7 and 5-ALA effects on pepper ripening, showing both accelerate ripening with differences in seed density and skin thickness.

Seaweed Amino Acid and L-Amino Acid Improve Coriander Growth

This study shows that seaweed amino acid (SG) and L-amino acid (LG) treatments enhance coriander growth and root development compared to a control group.

Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment

This study uses spatial multi-omics to compare EBV-positive and EBV-negative cHL, identifying distinct TME features and immunological signatures linked to EBV.