Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses
K. R. Prasanth, M. Hirano, W. S. Fagg, E. McAnarney, S. Chan, X. Xie, A. Hage, C. Pietzsch, A. Bukreyev, R. Rajsbaum, P.-Y. Shi, M. Bedford, S. Bradrick, V. D. Menachery, M. A. Garcia-Blanco
The paper identifies TOP3B as essential for replication of positive-sense RNA viruses, including SARS-CoV-2, suggesting it as a potential antiviral target.
bioRxiv · Mar 24, 2020Microbiology