R. Rajsbaum

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication

This study identifies TRIM7 as an E3-ubiquitin ligase that ubiquitinates SARS-CoV-2 M protein to inhibit apoptosis and viral replication.

Ebola Virus VP35 Interacts Non-Covalently with Ubiquitin Chains to Promote Viral Replication Creating New Therapeutic Opportunities

This study identifies a non-covalent interaction between Ebola virus VP35 and ubiquitin chains that supports viral replication and discovers compounds that block this interaction to reduce viral activity.

A novel mechanism of regulation of the transcription factor GLI3 by toll-like receptor signaling

This paper identifies TLR4-TRIF-IRF3 signaling as a novel pathway regulating GLI3 expression and its role in inflammatory cytokine secretion.

Type I interferon susceptibility distinguishes SARS-CoV-2 from SARS-CoV.

This study compares the sensitivity of SARS-CoV-2 and SARS-CoV to type I interferon, finding SARS-CoV-2 is more susceptible to IFN-I treatment.

Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses

The paper identifies TOP3B as essential for replication of positive-sense RNA viruses, including SARS-CoV-2, suggesting it as a potential antiviral target.

Peptidoglycan associated cyclic lipopeptide disrupts viral infectivity

The paper identifies surfactin, a cyclic lipopeptide from bacterial peptidoglycan, as a broad-spectrum virucidal compound that disrupts enveloped virus infectivity.

VAMP8 contributes to TRIM6-mediated type-I interferon antiviral response during West Nile virus infection

This paper identifies VAMP8 as a novel gene regulated by TRIM6 that enhances IFN-I signaling and restricts WNV replication in human cells.