A. Bukreyev

Multiple layers of innate immune response antagonism of SARS-CoV-2

This study generates twelve SARS-CoV-2 viruses with mutations in individual proteins and shows that many have interferon-antagonizing activity and immunosuppressive effects in human cells and mice, with NSP1 and NSP15 having the greatest impact.

Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection

This study shows intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 by inducing antibodies and reducing viral load and lung damage.

Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies

This study maps antigenic sites and characterizes neutralizing antibodies against hantaviruses, identifying mechanisms and cross-protective potential for vaccine development.

Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host directed antivirals.

The paper identifies eRF3a/GSPT1 as a druggable host target for antiviral therapy against Lassa virus by analyzing its interactome using proximity proteomics.

Lassa virus glycoprotein nanoparticles elicit a neutralizing antibody that defines a new site of vulnerability

This study develops Lassa virus glycoprotein nanoparticles that stabilize GPC trimers and elicit neutralizing antibodies targeting a new vulnerability site.

A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions

This paper describes a live-attenuated SARS-CoV-2 vaccine candidate with deleted ORFs that shows reduced replication and attenuation in animal models, and reports its protective efficacy against wild-type virus challenge.

Systematic analysis of human antibody response to ebolavirus glycoprotein reveals high prevalence of neutralizing public clonotypes

The paper analyzes the human antibody response to ebolavirus glycoprotein, identifying public clonotypes with neutralizing activity and implications for vaccine design.

Functional interactomes of the Ebola virus polymerase identified by proximity proteomics in the context of viral replication

The paper identifies functional interactors of the Ebola virus polymerase using proximity proteomics and validates their role in promoting viral replication.

Efficient discovery of potently neutralizing SARS-CoV-2 antibodies using LIBRA-seq with ligand blocking

This study demonstrates that integrating ligand blocking into LIBRA-seq improves the efficiency of identifying potent SARS-CoV-2 neutralizing antibodies.

Potent neutralization of SARS-CoV-2 variants of concern by an antibody with a unique genetic signature and structural mode of spike recognition

This study identifies a potent SARS-CoV-2 antibody, 54042-4, that neutralizes variants of concern and has a unique epitope and genetic structure.

Protective pan-ebolavirus combination therapy by two multifunctional human antibodies

This paper develops a therapeutic cocktail of two human antibodies that protect against multiple ebolaviruses in non-human primates and reveals their molecular mechanisms.

A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19

A single dose of the VSV-vectored vaccine ConVac expressing SARS-CoV-2 S1 subunit protects hamsters from weight loss and viral replication after SARS-CoV-2 challenge.

mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge

This study evaluates mRNA-1273 vaccine efficacy in hamsters, showing reduced pulmonary immune activation and improved disease outcomes after prime-boost vaccination.

Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model.

This study evaluates an inactivated rabies virus vectored SARS-CoV-2 vaccine in Syrian hamsters, showing protection against disease and viral replication.

A Novel SARS-CoV-2 Multitope Protein/Peptide Vaccine Candidate is Highly Immunogenic and Prevents Lung Infection in an AAV hACE2 Mouse Model and non-human primates

This paper describes a multitope protein-peptide vaccine candidate, UB-612, that is immunogenic and prevents lung infection in animal models, with ongoing clinical trials.

Convergence of a common solution to broad ebolavirus neutralization by glycan cap directed human antibodies

The paper presents cryo-EM structures of glycan cap antibodies that neutralize ebolavirus by targeting a conserved MLD-anchor site, revealing common features among broadly neutralizing antibodies.

EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K/eNOS-dependent manner during inflammation

This study shows EPAC1 regulates vWF secretion from endothelial cells during inflammation via the PI3K/eNOS pathway, with implications for thrombosis control.

Marburg and Ebola virus infections elicit a complex, muted inflammatory state in bats

This study investigates how Marburg and Ebola viruses elicit a complex, muted inflammatory response in bats, revealing mechanisms that may explain their non-pathogenicity in these animals.

Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses

The paper identifies TOP3B as essential for replication of positive-sense RNA viruses, including SARS-CoV-2, suggesting it as a potential antiviral target.

Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections

This study shows that ANXA2 depletion increases CMHs in rickettsia and Ebola virus infections by disrupting BBB tight junctions.

Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody

The paper determines the structure of a broadly neutralizing antibody against ebolavirus, identifies a conserved epitope, and explains factors affecting its activity against related viruses.