A Compensatory RNase E Variation Increases Iron Piracy and Virulence in Multidrug-Resistant Pseudomonas aeruginosa during Macrophage Infection
M. Vaillancourt, A. C. M. Galdino, S. P. Limsuwannarot, D. Celedonio, E. Dimitrova, M. Broerman, C. Bresee, Y. Doi, J. S. Lee, W. C. Parks, P. Jorth
This study shows that a compensatory RNase E mutation in P. aeruginosa increases siderophore production and macrophage ferroptosis, contributing to virulence and potentially being targeted by gallium therapy.
bioRxiv · Oct 24, 2022 · PreprintMicrobiology