Author

M. Castledine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Ecology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 4 Research Focus:host-pathogen & immune response· 4 Assay:metagenomics· 3 Research Focus:ecology & biodiversity· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Buckling· 5 shared D. Padfield· 5 shared R. Lewis· 2 shared A. Hughes· 1 shared A. Newbury· 1 shared D. De Vos· 1 shared D. Sanders· 1 shared D. Sunderhauf· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersEvolutionary Biology

A. Buckling

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Microbial community structure is affected by phage-resistance associated increases in host density

M. Castledine, D. Padfield, R. Lewis, A. Buckling

The paper shows that phage resistance in Variovorax sp. increases host density, altering microbial community structure by reducing conspecific density.

bioRxiv · Mar 7, 2024Microbiology

Parallel evolution of phage resistance - virulence trade - offs during in vitro and nasal Pseudomonas aeruginosa phage treatment

M. Castledine, D. Padfield, P. Sierocinski, J. Soria Pascual, A. Hughes, L. Mäkinen, V.-P. Friman, J.-P. Pirnay, M. Merabishvili, D. De Vos, A. Buckling

The paper investigates phage resistance evolution in Pseudomonas aeruginosa during in vitro and nasal treatments, finding similar resistance dynamics and reduced virulence in resistant strains.

bioRxiv · Sep 6, 2021Evolutionary Biology

Experimental multi-species microbial (co)evolution results in local maladaptation

M. Castledine, D. Padfield, A. Buckling

The paper co-evolves five microbial species in polycultures and monocultures, finding local maladaptation where evolved species show reduced growth in their evolved communities.

bioRxiv · Apr 26, 2020Evolutionary Biology

Characterising a stable five-species microbial community for use in experimental evolution and ecology.

M. Castledine, J. Pennycook, A. Newbury, L. Lear, Z. Erdos, R. Lewis, S. Kay, D. Sanders, D. Sunderhauf, A. Buckling, E. Hesse, D. Padfield

The paper reports the stable coexistence of a five-species microbial community derived from soil microbes, demonstrating long-term stability and species identification through plate morphologies.

bioRxiv · Apr 24, 2020 · PreprintEcology

Temperature-dependent changes to host-parasite interactions alter the thermal performance of a bacterial host.

D. Padfield, M. Castledine, A. Buckling

The study examines how temperature-dependent changes in a host-parasite interaction affect the thermal performance curve of a bacterial host.

bioRxiv · Feb 19, 2019Evolutionary Biology