Author

D. Sanders

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Ecology· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Organism:Arabidopsis· 1

Frequent Co-Authors

J. D. Brenton· 3 shared M. Vias· 3 shared A. Buckling· 2 shared A. Piskorz· 2 shared B. Hernando· 2 shared C. Sauer· 2 shared D.-L. Couturier· 2 shared F. Correia Martins· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

J. D. Brenton

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Predicting response to cytotoxic chemotherapy

J. Thompson, L. Madrid, B. Hernando, C. Sauer, M. Vias, M. Escobar-Rey, W.-K. Leung, J. Huckstep, M. Sekowska, K. Hosking, M. Jimenez-Linan, M. Reinius, H. Dobson, D. De Silva, A. Fernandez-Sanroman, , G. Macintyre

This study develops three precision biomarkers based on chromosomal instability signatures to predict response to different chemotherapies, showing improved progression-free survival in clinical trials.

bioRxiv · Jan 28, 2023Cancer Biology

The BRUTUS-LIKE E3 ligases BTSL1 and BTSL2 fine-tune transcriptional responses to balance Fe and Zn homeostasis

C. Stanton, J. Rodriguez-Celma, U. Kraemer, D. Sanders, J. Balk

This study shows that loss-of-function of BTSL1 and BTSL2, which suppress iron uptake, confers zinc tolerance in Arabidopsis, revealing a regulatory interaction between iron and zinc homeostasis.

bioRxiv · Dec 28, 2022 · PreprintPlant Biology

High-grade serous ovarian carcinoma organoids as models of chromosomal instability

M. Vias, L. Morrill Gavarro, C. M. Sauer, D. Sanders, A. M. Piskorz, D.-L. Couturier, S. Ballereau, B. Hernando, J. Hall, F. Correia-Martins, F. Markowetz, G. Macintyre, J. D. Brenton

This study develops HGSOC patient-derived organoids to model chromosomal instability and its mutational processes, showing they represent different causes of instability and can be used for drug sensitivity testing.

bioRxiv · Sep 1, 2022Cancer Biology

Antimicrobial resistance genes predict plasmid generalism and network structure in wastewater

A. Risely, T. Stalder, B. Simmons, E. M. Top, A. Buckling, D. Sanders

The paper uses Hi-C data to show AMR-carrying plasmids form more connected networks than non-AMR plasmids, enhancing AMR gene spread.

bioRxiv · May 11, 2022 · PreprintMicrobiology

Somatic chromosomal number alterations affecting driver genes inform in-vitro and clinical drug response in high-grade serous ovarian cancer

F. Correia Martins, D.-L. Couturier, I. Santiago, C. Sauer, M. Vias, M. Angelova, D. Sanders, A. Piskorz, J. Hall, K. Hosking, A. Amirthanayagam, S. Cosulich, L. Carnevalli, B. Davies, T. B. K. Watkins, , J. D. Brenton

This study shows that somatic copy number alterations in driver genes correlate with drug response in HGSOC spheroid models and clinical settings.

bioRxiv · Oct 4, 2020 · PreprintCancer Biology

Characterising a stable five-species microbial community for use in experimental evolution and ecology.

M. Castledine, J. Pennycook, A. Newbury, L. Lear, Z. Erdos, R. Lewis, S. Kay, D. Sanders, D. Sunderhauf, A. Buckling, E. Hesse, D. Padfield

The paper reports the stable coexistence of a five-species microbial community derived from soil microbes, demonstrating long-term stability and species identification through plate morphologies.

bioRxiv · Apr 24, 2020 · PreprintEcology