Muscle of obese insulin-resistant humans exhibits losses in proteostasis and attenuated proteome dynamics that are improved by exercise training.
K. Srisawat, C. A. Stead, K. Hesketh, M. Pogson, J. A. Strauss, M. Cocks, I. Siekmann, S. M. Phillips, P. J. Lisboa, S. Shepherd, J. G. Burniston
This study examines muscle proteostasis in obese insulin-resistant individuals and finds that endurance exercise improves proteome dynamics and proteostasis.
bioRxiv · Mar 16, 2023 · PreprintPhysiology