Crystal structure of m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon receptor binding.
D. Zajonc, A. Bitra, T. Doukov, G. Destito, M. Croft
This paper reports the crystal structure of mouse 4-1BBL and its complex with 4-1BB, revealing unique dimerization and structural changes upon binding that explain species-specific interactions.
bioRxiv · Oct 16, 2018Immunology