Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition
S. F. Cai, S. H. Chu, A. D. Goldberg, S. Parvin, R. P. Koche, J. L. Glass, E. M. Stein, M. S. Tallman, F. Sen, C. Famulare, M. Cusan, C.-H. Huang, C.-W. Chen, L. Zou, K. B. Cordner, , S. A. Armstrong
This study shows that leukemia cell of origin affects apoptotic priming and sensitivity to LSD1 inhibitors, with Evi1 modulating p53 stability and activity.
bioRxiv · May 11, 2020Cancer Biology