Author

M. D. Larsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

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Organism:human· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

G. Vidarsson· 4 shared M. Wuhrer· 4 shared J. Nouta· 3 shared A. P. J. Vlaar· 2 shared C. A. M. Koeleman· 2 shared C. E. van der Schoot· 2 shared F. Linty· 2 shared R. Visser· 2 shared

Activity by Year

2019-2022 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

G. Vidarsson

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4 papers

Recent·Most cited

The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylatedIgG1 in naive but not antigen-experienced vaccinees

J. Van Coillie, T. Pongracz, J. Rahmoeller, H.-J. Chen, C. E. Geyer, L. A. van Vught, J. S. Buhre, T. Sustic, T. L. J. van Osch, M. Steenhuis, W. Hoepel, W. Wang, A. Lixenfeld, J. Nouta, S. Keijzer, , Fatebenefratelli-Sacco Infectious Diseases Physic

The paper examines afucosylated IgG1 responses after BNT162b2 vaccination, finding transient responses in naive individuals that correlate with second-dose antibody levels.

bioRxiv · Feb 14, 2022Immunology

Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

M. D. Larsen, M. Lopez-Perez, E. K. Dickson, P. Ampomah, N. T. Ndam, J. Nouta, C. A. M. Koeleman, A. L. H. Ederveen, B. Mordmüller, A. Salanti, M. A. Nielsen, A. Massougbodji, C. E. van der Schoot, M. F. Ofori, M. Wuhrer, , G. Vidarsson

The paper shows that natural infection with Plasmodium falciparum induces afucosylated PfEMP1-specific IgG, while subunit vaccination produces fully fucosylated IgG.

bioRxiv · Apr 23, 2021Immunology

Afucosylated immunoglobulin G responses are a hallmark of enveloped virus infections and show an exacerbated phenotype in COVID-19

M. D. Larsen, E. L. de Graaf, M. E. Sonneveld, H. R. Plomp, F. Linty, R. Visser, M. Brinkhaus, T. Sustic, S. W. deTaeye, A. E. H. Bentlage, J. Nouta, S. Natunen, C. A. M. Koeleman, S. Sainio, N. A. Kootstra, , G. Vidarsson

The paper shows that afucosylated IgG responses are common in enveloped virus infections and are more severe in COVID-19, with implications for immune response and pathology.

bioRxiv · May 18, 2020Immunology

Natural killer cell activation by respiratory syncytial virus-specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc-glycosylation

E. A. van Erp, A. J. Lakerveld, E. de Graaf, M. D. Larsen, R. M. Schepp, A. L. Hipgrave Ederveen, I. M. L. Ahout, C. A. M. de Haan, M. Wuhrer, W. Luytjes, G. Ferwerda, G. Vidarsson, P. B. van Kasteren

The paper examines how RSV-specific antibodies from infants with severe respiratory infections activate NK cells and links this to Fc-glycosylation, finding reduced activation in infected infants.

bioRxiv · Nov 4, 2019Immunology