Author

F. Linty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

G. Vidarsson· 3 shared J. Nouta· 3 shared M. Wuhrer· 3 shared A. P. J. Vlaar· 2 shared H.-J. Chen· 2 shared J. den Dunnen· 2 shared M. D. Larsen· 2 shared M. P. J. de Winther· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

G. Vidarsson

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3 papers

Recent·Most cited

The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylatedIgG1 in naive but not antigen-experienced vaccinees

J. Van Coillie, T. Pongracz, J. Rahmoeller, H.-J. Chen, C. E. Geyer, L. A. van Vught, J. S. Buhre, T. Sustic, T. L. J. van Osch, M. Steenhuis, W. Hoepel, W. Wang, A. Lixenfeld, J. Nouta, S. Keijzer, , Fatebenefratelli-Sacco Infectious Diseases Physic

The paper examines afucosylated IgG1 responses after BNT162b2 vaccination, finding transient responses in naive individuals that correlate with second-dose antibody levels.

bioRxiv · Feb 14, 2022Immunology

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

W. Hoepel, H.-J. Chen, S. Allahverdiyeva, X. Manz, J. Aman, P. Bonta, P. Brouwer, S. de Taeye, T. Caniels, K. van der Straten, K. Golebski, G. Griffith, R. Jonkers, M. Larsen, F. Linty, , J. den Dunnen

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients induces hyper-inflammatory responses in macrophages, leading to endothelial barrier breakdown and microvascular thrombosis.

bioRxiv · Jul 13, 2020Immunology

Afucosylated immunoglobulin G responses are a hallmark of enveloped virus infections and show an exacerbated phenotype in COVID-19

M. D. Larsen, E. L. de Graaf, M. E. Sonneveld, H. R. Plomp, F. Linty, R. Visser, M. Brinkhaus, T. Sustic, S. W. deTaeye, A. E. H. Bentlage, J. Nouta, S. Natunen, C. A. M. Koeleman, S. Sainio, N. A. Kootstra, , G. Vidarsson

The paper shows that afucosylated IgG responses are common in enveloped virus infections and are more severe in COVID-19, with implications for immune response and pathology.

bioRxiv · May 18, 2020Immunology