Alpha-tubulin acetylation in Trypanosoma cruzi: a dynamic instability of microtubules is required for replication and cell cycle progression
V. L. Alonso, M. E. Carloni, C. Silva Goncalves, G. Martinez Peralta, M. E. Chesta, A. Pezza, L. E. Tavernelli, M. C. Machado Motta, E. C. Serra
This study shows that alpha-tubulin acetylation by TcATAT is essential for T. cruzi cell cycle progression and microtubule stability, with over-expression causing cell cycle arrest and drug resistance.
bioRxiv · Dec 15, 2020Cell Biology