Author

E. C. Serra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

V. L. Alonso· 2 shared A. Pezza· 1 shared C. Silva Goncalves· 1 shared E. Rodriguez Araya· 1 shared F. Calderon· 1 shared G. Martinez Peralta· 1 shared I. Pena· 1 shared J. Cantizani· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

V. L. Alonso

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Identification of novel Bromodomain inhibitors of Trypanosoma cruzi Bromodomain Factor 2 (TcBDF2) using a fluorescence polarization-base high-throughput assay

E. C. Serra, L. Tavernelli, V. L. Alonso, I. Pena, E. Rodriguez Araya, R. Manarin, J. Cantizani, J. Martin, J. Salamanca, P. Bamborough, F. Calderon, R. Gabarro

The paper develops a fluorescence polarization-based assay to identify bromodomain inhibitors of TcBDF2, finding 7 novel compounds that bind TcBDF2 with dissociation constants between 1 and 3 M.

bioRxiv · Feb 16, 2024 · PreprintMicrobiology

Alpha-tubulin acetylation in Trypanosoma cruzi: a dynamic instability of microtubules is required for replication and cell cycle progression

V. L. Alonso, M. E. Carloni, C. Silva Goncalves, G. Martinez Peralta, M. E. Chesta, A. Pezza, L. E. Tavernelli, M. C. Machado Motta, E. C. Serra

This study shows that alpha-tubulin acetylation by TcATAT is essential for T. cruzi cell cycle progression and microtubule stability, with over-expression causing cell cycle arrest and drug resistance.

bioRxiv · Dec 15, 2020Cell Biology