Author

M. E. Torrence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

B. D. Manning· 2 shared J. M. Asara· 2 shared A. J. Valvezan· 1 shared A. M. Hosios· 1 shared A. Valvezan· 1 shared E. P. Henske· 1 shared J. R. Mitchell· 1 shared M. C. McNamara· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

B. D. Manning

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Author profile →

2 papers

Recent·Most cited

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

M. E. Torrence, M. R. MacArthur, A. M. Hosios, A. Valvezan, J. M. Asara, J. R. Mitchell, B. D. Manning

This study shows that mTORC1 activates ATF4 to promote protein and glutathione synthesis, distinct from ISR-mediated ATF4 activation.

bioRxiv · Oct 3, 2020Cell Biology

IMPDH inhibitors for anti-tumor therapy in tuberous sclerosis complex

A. J. Valvezan, S. K. Miller, M. C. McNamara, M. E. Torrence, J. M. Asara, E. P. Henske, B. D. Manning

This paper evaluates IMPDH inhibitors for anti-tumor therapy in TSC, finding mizoribine more effective than mycophenolic acid in targeting mTORC1-driven tumors.

bioRxiv · Nov 11, 2019Cancer Biology