M. E. Wilkinson

Similar mechanisms of retron-mediated anti-phage defense for different families of tailed phages

This study identifies Retron-Eco11 as a bacterial defense system that uses helicase proteins to trigger effector toxicity against phage infection.

Data-driven regularisation lowers the size barrier of cryo-EM structure determination

This paper introduces a deep-learning-based regularisation method for cryo-EM that improves reconstruction quality, enabling structure determination of smaller macromolecules with low signal-to-noise ratios.

Structural basis for conformational equilibrium of the catalytic spliceosome

The paper presents an electron cryo-microscopy structure of the yeast C complex, revealing a novel intermediate that explains the conformational equilibrium of the spliceosome.