Repurposing melanoma chemotherapy to activate inflammasomes in treatment of BRAF/MAPK inhibitor-resistant melanoma
F. Ahmed, H.-Y. Tseng, A. Ahn, D. Gunatilake, S. Alavi, M. Eccles, H. Rizos, S. Gallagher, J. TIFFEN, P. Hersey, A. A. Emran
This study shows that temozolomide combined with chloroquine can induce pyroptosis in BRAF/MAPK inhibitor-resistant melanoma by activating different inflammasomes.
bioRxiv · Aug 23, 2021Cancer Biology