A. Chatterjee

G-Quadruplex Mediated c-myc Specific Downregulation: A Unique Pathway of the Anticancer Action of Immunomodulator Drugs

This study shows that HCQ and CQ downregulate c-myc oncogene transcription via G4 stabilization, reducing tumor growth and enhancing chemotherapy in breast cancer models.

Crosstalk between plasma membrane and Staphylococcus α-hemolysin during oligomerization

This study investigates the structural and functional dynamics of Staphylococcus aureus α-hemolysin during membrane interaction, revealing its role in cell necrosis and pore formation.

Enterococcal quorum-controlled protease alters phage infection

The paper investigates how Enterococcus faecalis protease GelE affects phage infection, finding that its reduction increases phage susceptibility and alters biofilm formation.

Identification and characterization of innate immunity in Actinidia melanandra in response to Pseudomonas syringae pv. actinidiae

This study identifies and characterizes innate immunity in Actinidia melanandra against Pseudomonas syringae pv. actinidiae, revealing PTI triggered by the T3S system.

Multiscale Correlations between Joint and Tissue-Specific Biomechanics and Anatomy in Postmortem Ovine Stifles

This study examines correlations between joint biomechanics and tissue-specific properties in ovine stifles to understand knee health indicators.

Characterization of Composite Agarose-Collagen Hydrogels for Chondrocyte Culture

This study creates composite agarose-collagen hydrogels to support chondrocyte culture and mechanotransduction, showing improved mechanical properties and glycosaminoglycan production over 21 days.

Large- and Small-Animal Studies of Safety, Pharmacokinetics (PK), and Biodistribution of Inflammasome-Targeting Nanoligomer in the Brain and Other Target Organs

This paper evaluates the safety, pharmacokinetics, and biodistribution of an inflammasome-targeting Nanoligomer cocktail in small and large animals across multiple administration routes.

Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy

This study shows that Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function in aged and tauopathy mouse models.

Curtailed CaSR expression in peripheral blood mononuclear cells is associated with hypertension

The paper investigates reduced CaSR expression in hypertensive models and links it to impaired NO production and altered Ca2+ dynamics.

Northeast India: Genetic Inconsistency across Ethnicity and Geography

The paper analyzes the genetic structure of Northeast India, finding a complex interplay between language, ethnicity, and geography, with a novel Trans-Himalayan ancestry uniting the region.

Role of Ethanolamine Utilization and Bacterial Microcompartment Formation in Listeria monocytogenes Intracellular Infection

This study investigates the role of ethanolamine utilization and bacterial microcompartment formation in Listeria monocytogenes intracellular infection, finding that EA utilization mutants show similar replication defects and immune responses as BMC formation mutants.

Cytosolic RNA binding of the mitochondrial TCA cycle enzyme malate dehydrogenase (MDH2)

This study identifies RNA-binding activity of mitochondrial MDH2, showing it preferentially binds cytosolic RNAs and its RNA-binding is influenced by NAD+ levels.

NbPTR1 confers resistance against Pseudomonas syringae pv. actinidiae in kiwifruit

This study identifies NbPTR1 as a resistance gene against Pseudomonas syringae pv. actinidiae in kiwifruit by introducing it into susceptible cultivars to confer resistance.

Heterogeneous identity, stiffness and growth characterise the shoot apex of Arabidopsis stem cell mutants

The paper investigates clavata mutant shoot apices in Arabidopsis, finding mechanical and functional heterogeneities that contribute to meristem overgrowth and buckling.

Pneumatically Controlled Non-Equibiaxial Cell Stretching Device with Live-cell Imaging

This paper develops a pneumatically controlled cell stretcher with live-cell imaging to study mechanical strain effects on cell behavior.

The homeodomain drives favorable DNA binding energetics of prostate cancer target ONECUT2

This study shows the homeodomain stabilizes ONECUT2-DNA binding through allosteric modulation and conserved base interactions, with implications for prostate cancer.

Recognition determinants of improved HIV-1 neutralization by a heavy chain matured pediatric antibody

This study characterizes a matured HIV-1 broadly neutralizing antibody from a pediatric donor, showing improved neutralization breadth and potency through structural analysis.

High Throughput Viability Assay for Microbiology

The paper introduces a high-throughput viability assay, GVA, that reduces time and resources compared to traditional CFU methods, enabling large-scale drug screening and discovery.

High resolution cryo-EM structures of two potently SARS-CoV-2 neutralizing monoclonal antibodies of same donor origin that vary in neutralizing Omicron variants

The paper presents high-resolution cryo-EM structures of two SARS-CoV-2 neutralizing mAbs from the same donor, showing differences in their binding to Omicron variants and conformational changes in the spike protein.

A Synthetic ERRα Agonist Induces an Acute AerobicExercise Response and Enhances Exercise Capacity

A synthetic ERRα agonist activates an acute aerobic exercise genetic program in skeletal muscle, enhancing exercise capacity and mitochondrial function in mice.

Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

This study shows that MFN2 deficiency leads to increased cytosolic Ca2+ and overactivation of RhoA and non-muscle myosin II, causing atypical peripheral actin band formation in mouse embryonic fibroblasts.

Genetically encoded non-canonical amino acids reveal asynchronous dark reversion of chromophore, backbone and side-chains in EL222

This study uses genetically encoded amino acids to reveal asynchronous dark reversion dynamics in the EL222 photoreceptor, showing local structural changes precede global conformational relaxation.

Safety and biodistribution of NanoligomersTM targeting SARS-CoV-2 genome for treatment of COVID-19

This paper evaluates the safety and biodistribution of a novel Nanoligomer targeting SARS-CoV-2 in mice, showing it is safe, nontoxic, and effectively distributed throughout the body.

Substrate stiffness modulates integrin α5 expression and ECM-associated gene expression in fibroblasts

This study shows that substrate stiffness affects integrin α5 and ECM-related gene expression in fibroblasts, influencing cell morphology, proliferation, and TGF-β signaling.

Effector loss drives adaptation of Pseudomonas syringae pv. actinidiae to Actinidia arguta

This study identifies effector loss in Pseudomonas syringae pv. actinidiae as a driver of adaptation to Actinidia arguta, revealing key effectors involved in host resistance.

Loss of GdpP function in Staphylococcus aureus leads to β-lactam tolerance and enhanced evolution of β-lactam resistance

This study shows that loss of GdpP function in Staphylococcus aureus increases β-lactam tolerance and facilitates the evolution of β-lactam resistance.

Cystinosin deficient rats recapitulate the phenotype of nephropathic cystinosis

This paper develops a new cystinosis rat model using CRISPR/Cas9 to recapitulate the disease phenotype and progression more accurately than existing models.

Transcriptional reprogramming and constitutive PD-L1 expression in melanoma are associated with dedifferentiation and activation of interferon and tumor necrosis factor signaling pathways

Altered DNA methylation in ion transport and immune signalling genes is associated with severity in Pancreatic Ductal Adenocarcinoma

This study identifies DNA methylation changes in PDAC associated with disease severity and finds concordance with TCGA-PAAD and GTEx datasets.

The mouse papillomavirus epigenetic signature is characterised by DNA hypermethylation after lesion regression

The paper identifies DNA hypermethylation in regressed mouse papillomavirus lesions that may contribute to increased susceptibility to UV-induced cancer.