SIRT6 is a DNA double-strand break sensor
D. Toiber, L. Onn, G. Cleitman, S. Ilic, M. Portillo, D. Stein, Z. Slobodnik, S. Kaluski, M. Einav, F. Erdel, I. Shirat, B. Akabayov
This study identifies SIRT6 as a DNA double-strand break sensor that activates downstream repair pathways and prevents genomic instability.
bioRxiv · Sep 11, 2019Biochemistry