D. Stein

Structural Analysis of Genomic and Proteomic Signatures Reveal Dynamic Expression of Intrinsically Disordered Regions in Breast Cancer and Tissue

The paper introduces SAGES, a method using structural features to analyze proteomic and transcriptomic data, revealing dynamic expression of intrinsically disordered regions in breast cancer and drug perturbation relationships.

Hybrid immunity shifts the Fc-effector quality of SARS-CoV-2 mRNA vaccine-induced immunity

This study compares the humoral immune response in individuals with and without prior COVID-19 after mRNA vaccination, finding that hybrid immunity enhances Fc-effector quality rather than quantity.

Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma

This study characterizes human Syx, a RhoGEF involved in glioblastoma, and performs computational simulations to elucidate its structure and allosteric regulation.

Nanopore ion sources deliver single amino acid and peptide ions directly into high vacuum

This paper introduces a nanopore ion source for mass spectrometry that delivers ions directly into high vacuum, enabling more sensitive proteomic analyses by avoiding sample loss mechanisms in conventional electrospray ionization.

Expansion of tissue-resident CD8+ T cells and CD4+ Th17 cells in the nasal mucosa following mRNA COVID-19 vaccination

This study examines changes in nasal T cell populations after mRNA COVID-19 vaccination, finding expansion of CD8+ T cells and CD4+ Th17 cells.

Gonococcal invasion into epithelial cells depends on both cell polarity and ezrin

This study shows that Neisseria gonorrhoeae invades non-polarized cervical epithelial cells more efficiently than polarized ones, driven by ezrin phosphorylation and actin dynamics.

Exonic Disruption Facilitates Antiviral CRISPR-Cas9 Activity for Multistrain HIV-1 Elimination

This paper designs CRISPR-Cas9 guide RNAs targeting HIV-1 exons to reduce viral load in infected cells without off-target effects.

Mice with Induced Pulmonary Comorbidities Display Severe Lung Inflammation and Mortality following Exposure to SARS-CoV-2

This study shows that CD-1 mice with induced pulmonary comorbidities develop severe lung inflammation and high mortality after SARS-CoV-2 infection.

The coding capacity of SARS-CoV-2

This study maps the full coding capacity of SARS-CoV-2 using ribosome profiling, identifying 23 novel translated ORFs and revealing viral translation dominance over host translation.

A single dose of recombinant VSV-{triangleup}G-spike vaccine provides protection against SARS-CoV-2 challenge

This study develops a recombinant VSV-ΔG-spike vaccine that provides single-dose protection against SARS-CoV-2 in hamsters by inducing neutralizing antibodies and preventing lung pathology.

Evaluating the efficacy of RT-qPCR SARS-CoV-2 direct approaches in comparison to RNA extraction

The paper compares RT-qPCR efficacy with and without RNA extraction for SARS-CoV-2 detection, finding that extraction is advantageous but a direct no-buffer approach can identify up to 70% of clinical specimens.

SIRT6 is a DNA double-strand break sensor

This study identifies SIRT6 as a DNA double-strand break sensor that activates downstream repair pathways and prevents genomic instability.