Genetic screening for single-cell variability modulators driving therapy resistance
E. A. Torre, E. Arai, S. Bayatpour, L. E. Beck, B. L. Emert, S. M. Shaffer, I. A. Mellis, M. Fane, G. Alicea, K. A. Budinich, A. Weeraratna, J. Shi, A. Raj
This study identifies genes that modulate cellular plasticity and influence therapy resistance in cancer cells through CRISPR screens, showing that manipulating plasticity before therapy can alter resistance.
bioRxiv · Nov 10, 2019Cell Biology