A. Raj

Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice

The paper analyzes longitudinal body weight data in mice to identify traits linked to lifespan, finding heritable traits associated with energy homeostasis and longevity.

Interactions between the gut microbiome, dietary restriction, and aging in genetically diverse mice

This study investigates how the gut microbiome interacts with aging and dietary restriction in mice, finding that host genetics significantly influence microbiome features and that dietary restriction does not rejuvenate the microbiome.

Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer

This study shows nuclear speckles vary in cancer, correlate with survival in kidney cancer, and are regulated by HIF-2 through speckle targeting motifs.

Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states

This study identifies cell state variability as a key determinant of SARS-CoV-2 susceptibility by analyzing highly susceptible lung epithelial cells.

Bayesian Inference for Brain Source Imaging with Joint Estimation of Structured Low-rank Noise

This paper introduces a Bayesian framework for brain source imaging that jointly estimates low-rank noise and sparse brain activity, outperforming existing methods on simulated and real data.

Time-varying Dynamic Network Model For Dynamic Resting State Functional Connectivity in fMRI and MEG imaging

This paper introduces a time-varying dynamic network model to analyze dynamic resting state functional connectivity in fMRI and MEG data, showing improved performance in capturing brain dynamics and detecting state transitions.

Metastatic potential in clonal melanoma cells is driven by a rare, early-invading subpopulation

The paper identifies a rare invasive subpopulation of melanoma cells that drives metastasis, independent of environment, through non-genetic gene expression fluctuations.

clampFISH 2.0 enables rapid, scalable amplified RNA detection in situ

clampFISH 2.0 enables rapid, scalable detection of multiple RNA species in single cells and tissue sections by improving signal amplification and reducing time and cost.

Cortical structure of neural synchrony and information flow during transition from wakefulness to light non-rapid eye movement sleep

The paper quantifies whole-brain network changes in neural synchrony and information flow during wake-to-NREM sleep transition using MEG and computational modeling.

Anti-inflammatory and neuroprotective activity of Viphyllin a standardized extract of β-caryophyllene from black pepper (Piper Nigrum L) and its associated mechanisms in mouse macrophage cells and Human Neuroblastoma SH-SY5Y cells

This study evaluates the anti-inflammatory and neuroprotective effects of Viphyllin, a β-caryophyllene extract, in macrophage and neuroblastoma cells, showing reduced inflammation and apoptosis.

Post-transcriptional splicing can occur in a slow-moving zone around the gene

The paper uses imaging techniques to show that splicing occurs in a slow-moving zone near the transcription site, suggesting a model where splicing is post-transcriptional but occurs close to transcription.

Genetic screening for single-cell variability modulators driving therapy resistance

This study identifies genes that modulate cellular plasticity and influence therapy resistance in cancer cells through CRISPR screens, showing that manipulating plasticity before therapy can alter resistance.

A Maxent modelling with a geospatial approach for the Habitat suitability of Flamingos in an Evanescing Ramsar site (Sambhar Lake, India) over the changing climatic scenarios

This study uses Maxent modeling to assess habitat suitability for flamingos in Sambhar Lake, India, under changing climate scenarios, finding that anthropogenic activities have reduced suitable habitat.

Parameter Identifiability and Non-Uniqueness in connectome based neural mass models

This study examines parameter identifiability and non-uniqueness in connectome-based neural mass models, finding that regional parameter models produce non-unique results and face challenges in diagnostic applications.

SCGN Administration prevents Insulin Resistance and Diabetic Complications in High-Fat Diet Fed Animals

This study shows that administering SCGN improves insulin response and alleviates diabetic complications in high-fat diet-fed animals.

Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence

This study shows replication defective viral genomes (DVGs) protect certain cells from death and promote viral persistence by activating a TNF-mediated survival pathway during infection.

Intercellular mRNA Trafficking Via Membrane Nanotubes In Mammalian Cells

This paper demonstrates that full-length mRNAs transfer between mammalian cells via membrane nanotubes, not extracellular vesicles, and shows this process alters the acceptor cell proteome.