Author

M. Ferla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:simulation· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

A. A. Lee· 1 shared A. Li· 1 shared A. von Delft· 1 shared C. G. Acevedo-Rocha· 1 shared D. FearoniD· 1 shared F. von DelftiD· 1 shared J. D. Chodera· 1 shared J. Sanchis Martinez· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. A. Lee

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors

M. L. Bobby, D. Fearon, M. Ferla, M. Filep, L. Koekemoer, M. C. Robinson, The COVID Moonshot Consortium, J. D. Chodera, A. A. Lee, N. London, A. von Delft, F. von Delft

The paper describes an open-science drug discovery campaign that identified a non-covalent, non-peptidic inhibitor of SARS-CoV-2 main protease using crowdsourcing and computational methods.

bioRxiv · Oct 29, 2020 · PreprintBiochemistry

Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics

C. G. Acevedo-Rocha, A. Li, L. D'Amore, S. Hoebenreich, J. Sanchis Martinez, P. Lubrano, M. Ferla, M. Garcia Borras, S. Osuna, M. T. Reetz

The paper quantifies cooperative mutational effects on multiple catalytic traits of a cytochrome P450 enzyme using computational methods and simulations, showing their modulation by long-range conformational dynamics.

bioRxiv · Apr 14, 2020Evolutionary Biology