The accomplices: Heparan sulfates and N-glycans foster SARS-CoV-2 spike:ACE2 receptor binding and virus priming
G. Paiardi, M. Ferraz, M. Rusnati, R. C. Wade
This paper uses molecular dynamics simulations to show that heparan sulfate and N-glycans stabilize the SARS-CoV-2 spike:ACE2 complex and promote viral entry by triggering structural changes.
bioRxiv · Feb 5, 2024Biophysics