Smad3 Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic Plaque
P. Cheng, r. Wirka, J. Kim, T. Nguyen, R. Kundu, q. Zhao, A. Pedroza, M. Nagao, D. Iyer, M. Fischbein, T. Quertermous
This study shows that Smad3 in smooth muscle cells prevents harmful plaque changes in atherosclerosis by blocking specific cell transitions that lead to calcification and inflammation.
bioRxiv · Sep 15, 2020 · PreprintCell Biology