The oncoprotein DEK affects the outcome of PARP1/2 inhibition during replication stress
E. Ferrando-May, M. Ganz, C. Vogel, C. Czada, V. Jörke, R. Kleiner, A. Pierzynska-Mach, F. C. Zanacchi, A. Diaspro, F. Kappes, A. Bürkle
This study shows that DEK interacts with PAR to influence replication fork progression under stress, affecting PARP1/2 inhibitor efficacy in cancer cells.
bioRxiv · Feb 19, 2019Cancer Biology