Cancer BiologybioRxiv
The oncoprotein DEK affects the outcome of PARP1/2 inhibition during replication stress
E. Ferrando-May, M. Ganz, C. Vogel…·A. Bürkle
This study shows that DEK interacts with PAR to influence replication fork progression under stress, affecting PARP1/2 inhibitor efficacy in cancer cells.
DOI 10.1371/journal.pone.0213130