Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma.
A. Palamidessi, C. Malinverno, E. FRITTOLI, S. Corallino, E. Barbieri, S. Sigismund, P. P. Di Fiore, G. V. Beznoussenko, E. Martini, M. Garre, D. Parazzoli, I. Ferrara, C. Tripodo, F. Giavazzi, R. Cerbino, G. Scita
This study identifies the RAB5A-driven endo-ERK1/2 pathway as a mechanism for unjamming in epithelial tissues and carcinoma, enabling collective motility and invasion.
bioRxiv · Sep 17, 2018Cancer Biology