IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus
M. H. Guney, K. Nagalekshmi, S. M. McCauley, C. Carbone, O. Aydemir, J. Luban
This study identifies IFIH1 (MDA5) as essential for innate immune detection of intron-containing RNA from the HIV-1 provirus, linking it to chronic inflammation in HIV-1 patients.
bioRxiv · Nov 17, 2023 · PreprintMicrobiology