C. Carbone

Population dynamics after pancreatitis dictates long-lasting epigenetic reprogramming and mediates tumor predisposition

This study shows that acute pancreatitis induces epigenetic changes in acinar cells, leading to long-term tumor predisposition through altered cell states and plasticity.

Variable responses of individual species to tropical forest degradation

The study examines how individual species respond to tropical forest degradation, finding significant variation in responses across populations and surveys.

IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus

This study identifies IFIH1 (MDA5) as essential for innate immune detection of intron-containing RNA from the HIV-1 provirus, linking it to chronic inflammation in HIV-1 patients.

Differential Activity of MAPK signalling Defines Fibroblast Subtypes in Pancreatic Cancer

This study identifies MAPK signalling as defining fibroblast subtypes in pancreatic cancer, linking MAPKhigh CAFs to poor prognosis and immune evasion.

The axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

This study shows SEMA3A promotes aggressive basal-like PDAC by enhancing metastasis and modulating the tumor microenvironment through macrophage polarization and T cell exclusion.

Transcriptomic dissection of Intraepithelial Papillary Mucinous Neoplasms progression by spatial technologies identified novel markers of pancreatic carcinogenesis.

This study uses spatial transcriptomics to identify novel markers and mechanisms of IPMN progression to PDAC, revealing distinct cell clusters and transcription factors associated with different grades of malignancy.

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

This study shows the D614G SARS-CoV-2 spike protein variant is more infectious but has reduced ACE2 affinity and altered trimer conformation, affecting viral entry and antibody neutralization.

Cyclophilin A protects HIV-1 from restriction by human TRIM5α

This study shows that Cyclophilin A protects HIV-1 from restriction by human TRIM5α by shielding the viral capsid from early inhibition during infection.

A century of decline: loss of genetic diversity in a southern African lion-conservation stronghold

This study compares genetic diversity in modern and historical African lion populations in KAZA, finding a 12-17% reduction in genetic diversity linked to colonialism and rinderpest.