Author

M. Heimhalt

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Biochemistry· 1

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Berndt· 1 shared A. Boland· 1 shared C. W.-H. Yu· 1 shared G. N. Murshudov· 1 shared G. R. Masson· 1 shared J. L. Wagstaff· 1 shared K. Yamashita· 1 shared M. Anandapadamanaban· 1 shared

Activity by Year

2021-2021 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

A. Berndt

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1 paper

Recent·Most cited

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

R. L. Williams, M. Heimhalt, A. Berndt, J. L. Wagstaff, M. Anandapadamanaban, O. Perisic, S. Maslen, S. H. McLaughlin, C. W.-H. Yu, G. R. Masson, A. Boland, X. Ni, K. Yamashita, G. N. Murshudov, M. Skehel, S. M. Freund

This study investigates the interaction between DEPTOR and mTORC1, revealing DEPTOR as a partial inhibitor that is more effective against activated mTORC1, with mutual antagonism mediated by phosphorylation and structural interactions.

bioRxiv · Apr 28, 2021Biochemistry