Author

A. Boland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J.-F. Deleuze· 2 shared S. H. McLaughlin· 2 shared A. Berndt· 1 shared A. Hoefler· 1 shared B. Vojtkova· 1 shared C. Besse· 1 shared C. Proux· 1 shared C. W.-H. Yu· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersEvolutionary Biology

J.-F. Deleuze

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

New structural features of the APC/C revealed by high resolution cryo-EM structures of apo-APC/C and the APC/C CDH1:EMI1 complex

A. Hoefler, J. Yu, J. Yang, Z. Zhang, L. Chang, S. H. McLaughlin, G. W. Grime, E. F. Garman, A. Boland, D. Barford

This study uses cryo-EM to determine high-resolution structures of apo-APC/C and APC/C CDH1:EMI1, revealing new structural features and regulatory mechanisms.

Nature Communications · Nov 21, 2024Peer-reviewedCell Biology

Positive selection in the genomes of two Papua New Guinean populations at distinct altitude levels

M. Andre, N. Brucato, G. Hudjasov, V. Pankratov, D. Yermakovich, R. Kreevan, J. Kariwiga, J. Muke, A. Boland, J.-F. Deleuze, V. Meyer, N. Evans, M. P. Cox, M. Leavesley, M. Dannemann, , F.-X. Ricaut

This study identifies genomic regions under positive selection in highland and lowland PNG populations, linking them to hypoxia, immunity, and archaic introgression.

bioRxiv · Dec 15, 2022Evolutionary Biology

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

R. L. Williams, M. Heimhalt, A. Berndt, J. L. Wagstaff, M. Anandapadamanaban, O. Perisic, S. Maslen, S. H. McLaughlin, C. W.-H. Yu, G. R. Masson, A. Boland, X. Ni, K. Yamashita, G. N. Murshudov, M. Skehel, S. M. Freund

This study investigates the interaction between DEPTOR and mTORC1, revealing DEPTOR as a partial inhibitor that is more effective against activated mTORC1, with mutual antagonism mediated by phosphorylation and structural interactions.

bioRxiv · Apr 28, 2021Biochemistry

Experimental evolution reveals post-transcriptional regulation as a novel driver of Leishmania fitness gain

L. Piel, K. S. Rajan, G. Bussotti, H. Varet, R. Legendre, C. Proux, T. Douche, Q. Giai Gianetto, T. Chaze, T. Cokelaer, B. Vojtkova, N. Gordon-Bar, T. Doniger, S. Cohen-Chalamish, P. Rengaraj, , G. F. Spaeth

This study shows that post-transcriptional regulation, not just genome instability, drives fitness gain in Leishmania parasites during in vitro adaptation.

bioRxiv · Mar 22, 2021 · PreprintMicrobiology