Author

O. Perisic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1

Frequent Co-Authors

R. L. Williams· 3 shared M. Anandapadamanaban· 2 shared A. Berndt· 1 shared A. Boland· 1 shared A. Y. Warren· 1 shared C. N. Pacyna· 1 shared C. W.-H. Yu· 1 shared G. D. Stewart· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

R. L. Williams

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Author profile →

3 papers

Recent·Most cited

Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis

C. N. Pacyna, M. Anandapadamanaban, K. W. Loudon, I. M. Hay, O. Perisic, R. Li, M. Byrne, L. Allen, K. Roberts, Y. Hooks, A. Y. Warren, G. D. Stewart, M. R. Clatworthy, S. Teichmann, S. Behjati, , T. J. Mitchell

The paper traces the origin of four synchronous renal tumours in a child to an early embryonic MTOR mutation, showing its role in tumour development and clinical implications.

bioRxiv · Dec 12, 2023Cancer Biology

Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

P. R. Tomlinson, R. Knox, O. Perisic, H. Su, G. V. Brierley, R. L. Williams, R. K. Semple

The paper investigates an activating PIK3R1 variant linked to immunodeficiency and finds it acts as a dominant negative, reducing p110 signaling and explaining overlapping phenotypes.

bioRxiv · Nov 2, 2023Biochemistry

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

R. L. Williams, M. Heimhalt, A. Berndt, J. L. Wagstaff, M. Anandapadamanaban, O. Perisic, S. Maslen, S. H. McLaughlin, C. W.-H. Yu, G. R. Masson, A. Boland, X. Ni, K. Yamashita, G. N. Murshudov, M. Skehel, S. M. Freund

This study investigates the interaction between DEPTOR and mTORC1, revealing DEPTOR as a partial inhibitor that is more effective against activated mTORC1, with mutual antagonism mediated by phosphorylation and structural interactions.

bioRxiv · Apr 28, 2021Biochemistry