Author

M. Hotze

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

A.-S. Egger· 2 shared L. E. Timpen· 2 shared T. Kipura· 2 shared A. Gollowitzer· 1 shared A. Hofer· 1 shared A. Kowar· 1 shared A. Leytens· 1 shared A. M. Heberle· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

A.-S. Egger

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2 papers

Recent·Most cited

Automated liquid handling extraction and rapid quantification of underivatized amino acids and tryptophan metabolites from human serum and plasma using dual-column U(H)PLC-MRM-MS and its application to prostate cancer study.

T. Kipura, M. Hotze, A. Hofer, A.-S. Egger, L. E. Timpen, C. Opitz, P. Townsend, L. Gethings, K. Thedieck, M. Kwiatkowski

The paper develops an automated workflow and dual-column U(H)PLC-MRM-MS method to rapidly quantify amino acids and tryptophan metabolites in human serum and plasma, applied to a prostate cancer study to identify biomarkers.

Metabolites · Jun 30, 2024Peer-reviewedBiochemistry

The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress

P. Holfelder, L. Hensen, M. T. Prentzell, P. Razquin Navas, M. Solvay, A. Sadik, D. Sayeeram, U. Rehbein, T. Bausbacher, A.-S. Egger, L. Regin, A. M. Heberle, S. Seifert, A. Leytens, A. Kowar, , S. Harder

This study identifies the MTORC1-AHR pathway as a mechanism sustaining translation and autophagy in tumors under tryptophan stress by enhancing AHR activity and autophagy regulators.

bioRxiv · Jan 16, 2023 · PreprintBiochemistry