K18-hACE2 mice develop respiratory disease resembling severe COVID-19
C. K. Yinda, J. R. Port, T. J. Bushmaker, I. Offei Owusu, V. A. Avanzato, R. J. Fischer, J. E. Schulz, M. G. Holbrook, M. J. Hebner, R. Rosenke, T. Thomas, A. Marzi, S. M. Best, E. de Wit, C. Shaia, , V. Munster
This paper shows that K18-hACE2 mice develop severe respiratory disease upon SARS-CoV-2 infection, resembling human severe COVID-19 with lung pathology and systemic inflammation.
bioRxiv · Aug 11, 2020Microbiology