T. Thomas

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

Enigmatic missense mutations can cause disease via creation of de novo nuclear export signals

The paper identifies missense mutations that create nuclear export signals, leading to disease, and shows therapeutic strategies can restore function.

Relative importance of MCL-1's Anti-Apoptotic versus Non-Apoptotic Functions in vivo

This study replaces MCL-1 with other anti-apoptotic proteins in mice to determine the relative importance of MCL-1's anti-apoptotic versus non-apoptotic functions in development and physiology.

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

This study creates a therapeutic atlas of anti-TNF treatment in IBD, showing disease- and therapy-specific cellular changes and identifying IFN signalling as a potential target for JAK inhibition.

CD99 Promotes Self-renewal in Hematopoietic Stem Cells and Leukemia Stem Cells by Regulating Protein Synthesis

This study shows CD99 regulates protein synthesis in hematopoietic stem cells and leukemia stem cells, promoting self-renewal and clonal expansion leading to AML.

Reticulocytes in donor RBC units enhance RBC alloimmunization

This study shows that reticulocytes in donor RBC units increase alloimmunization rates in mice by enhancing alloantibody levels and proinflammatory responses.

A monoclonal antibody targeting the Nipah virus fusion glycoprotein apex imparts protection from disease

This study identifies a monoclonal antibody, mAb92, that targets the Nipah virus fusion glycoprotein and provides complete protection in hamsters.

Reference compounds for characterizing cellular injury in high-content cellular morphology assays

The paper profiles 218 cytotoxic and nuisance compounds in U-2 OS cells to create reference compounds for improving assay optimization and compound prioritization in cellular morphology assays.

Mutant SF3B1 promotes PDAC malignancy through TGF-β resistance

This study shows that SF3B1K700E mutation in PDAC enhances tumor aggressiveness when combined with KRAS and p53 mutations by promoting TGF-β resistance.

Inhibition of advanced glycation end product formation and serum protein infiltration in bioprosthetic heart valve leaflets: Investigations of anti-glycation agents.

This study investigates anti-AGE agents' effects on AGE and serum protein infiltration in bioprosthetic heart valves using in vitro and in vivo models, finding that PYR significantly inhibits AGE and serum albumin accumulation.

Optimization of single dose VSV-based COVID-19 vaccination in hamsters

This study evaluates two VSV-based COVID-19 vaccines in hamsters, showing intranasal vaccination provides rapid protection against multiple SARS-CoV-2 variants.

School yard biodiversity determines short-term recovery of disturbed skin microbiota in children

This study shows that exposure to biodiverse environments like forests increases skin microbiota diversity in children more than sports fields or classrooms.

Multi-omics profiling of Earth's biomes reveals patterns of diversity and co-occurrence in microbial and metabolite composition across environments

The paper performs a multi-omics meta-analysis of microbial and metabolite data from diverse environments, revealing patterns of diversity and co-occurrence across biomes.

Hematologic and systemic metabolic alterations due to Mediterranean type II G6PD deficiency in a novel murine model

This study creates a novel murine model of severe G6PD deficiency by introducing a human mutation, revealing metabolic alterations and hemolytic sequelae similar to humans.

ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7 1 disease

This study shows that the ChAdOx1 nCoV-19 vaccine protects Syrian hamsters from SARS-CoV-2 B.1.1.7 and B.1.351 variants, preventing weight loss, lung lesions, and viral replication.

Rare genera differentiate urban green space soil bacterial communities in three cities across the world

The paper examines the relationship between vegetation complexity and soil bacterial communities in urban green spaces across three cities, finding that rare genera significantly differ between vegetation complexity categories.

IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease

Rapid protection from COVID-19 in nonhuman primates vaccinated intramuscularly but not intranasally with a single dose of a recombinant vaccine

A single-dose VSV-based vaccine protected nonhuman primates from COVID-19 within 10 days when administered intramuscularly but not intranasally.

K18-hACE2 mice develop respiratory disease resembling severe COVID-19

This paper shows that K18-hACE2 mice develop severe respiratory disease upon SARS-CoV-2 infection, resembling human severe COVID-19 with lung pathology and systemic inflammation.

IER5, a DNA-damage response gene, is required for Notch-mediated induction of squamous cell differentiation

The paper identifies IER5 as a Notch-induced DNA-damage response gene required for squamous cell differentiation and shows its interaction with PP2A subunit PPP2R2A.

Microbial predictors of environmental perturbations in coral reef ecosystems

This study evaluates the diagnostic value of microbial communities in coral reef ecosystems to predict environmental perturbations, finding that free-living microbiomes are more sensitive and informative than host-associated ones.

A synergistic transcriptional regulation of olfactory genes derives complex behavioral responses in the mosquito Anopheles culicifacies

This study identifies synergistic regulation of olfactory genes in Anopheles culicifacies that drive complex blood feeding behaviors and predicts novel sensory proteins involved in host seeking.

The application of zeta diversity as a continuous measure of compositional change in ecology

This paper applies zeta diversity to study compositional change across multiple biological systems, showing its utility in capturing biodiversity turnover patterns.