Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein
D. Noone, M. Isendoorn, S. Hamers, M. Keizer, J. T. Wulffele, T. van der Velden, D. Dijkstra, L. Trouw, D. Filippov, T. Sharp
This paper presents a cryo-ET structure of CRP bound to C1 complex and PC ligands, revealing how CRP activates complement and identifies residues for therapeutic targeting.
bioRxiv · Mar 18, 2024Immunology