T. Sharp

Increased 5-HT2A receptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelics

This study compares 5-HT2A receptor signalling efficacy and bias between serotonergic psychedelics and non-psychedelics, finding that efficacy, not bias, distinguishes them.

Correlating Protein Aggregate Structure with Cellular Function in Differentiated Muscle Cells: Discriminating Pathogenic from Non-Pathogenic Forms

This study correlates the structure of pathogenic and non-pathogenic PABPN1 protein aggregates with cellular function in differentiated muscle cells using multimodal imaging.

The remarkable similarity in the serum proteome between type 2 diabetics and controls

This study finds the serum proteome is remarkably similar between type 2 diabetics and controls, with major differences being glycations of abundant proteins and associations between BMI and a ternary complex.

Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein

This paper presents a cryo-ET structure of CRP bound to C1 complex and PC ligands, revealing how CRP activates complement and identifies residues for therapeutic targeting.

INSULIN-LIKE GROWTH FACTOR I REDUCES CORONARY ATHEROSCLEROSIS IN PIGS WITH FAMILIAL HYPERCHOLESTEROLEMIA

This study shows that IGF-1 reduces coronary atherosclerosis and promotes stable plaque features in FH pigs, with spatial transcriptomics revealing potential mechanistic insights.