Peptidomimetic blockade of MYB in acute myeloid leukemia
K. Ramaswamy, L. Forbes, G. Minuesa, T. Gindin, F. Brown, M. Kharas, A. Krivtsov, S. Armstrong, E. Still, E. de Stanchina, B. Knoechel, R. Koche, A. Kentsis
This study develops a peptidomimetic inhibitor, MYBMIM, that blocks MYB:CBP/P300 complex assembly in AML cells, leading to apoptosis and reduced tumor growth in mice.
bioRxiv · Nov 20, 2017Cancer Biology