F. Brown

Chemo-phosphoproteomic profiling with ATR inhibitors berzosertib and gartisertib uncovers new biomarkers and DNA damage response regulators

The paper identifies novel ATR-dependent phospho-proteomic targets and reveals new biomarkers and genome maintenance factors through screening with ATR inhibitors.

Interaction with C21ORF2 controls the cellular functions of the NEK1 kinase

This study identifies C21ORF2 as a regulatory subunit of NEK1, showing that their interaction is critical for NEK1 function and that mutations disrupt this interaction, linking it to disease.

Steroid hormone agonists reduce female fitness in insecticide-resistant Anopheles populations

This study shows that applying methoxyfenozide reduces egg production and adult longevity in insecticide-resistant Anopheles mosquitoes, suggesting it could complement malaria control strategies.

KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria.

This study shows that KCC1 activation protects mice from experimental cerebral malaria by increasing CD4+ T cells and TNF- response.

Peptidomimetic blockade of MYB in acute myeloid leukemia

This study develops a peptidomimetic inhibitor, MYBMIM, that blocks MYB:CBP/P300 complex assembly in AML cells, leading to apoptosis and reduced tumor growth in mice.

Efficient hydrogen-dependent carbon dioxide reduction by Escherichia coli

This paper demonstrates that Escherichia coli's formate hydrogenlyase complex can efficiently reduce carbon dioxide to formate under controlled pressure conditions.

MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia

This study identifies MEF2C phosphorylation as a marker of chemotherapy resistance in AML and shows that inhibiting this phosphorylation can overcome resistance in MEF2C-activated cells.