ER - lysosome contacts at a pre-axonal region regulate axonal lysosome availability
N. Ozkan, M. Koppers, I. van Soest, A. van Harten, N. Liv, J. Klumperman, C. C. Hoogenraad, G. G. Farias
The paper shows that ER tubules regulate lysosome transport into axons by promoting lysosome homo-fission and fission-driven translocation, with ER-lysosome contacts at a pre-axonal region facilitating this process.
Nature Communications · Jul 23, 2021Peer-reviewedCell Biology