The phosphatase PTPRG controls FGFR1 activity and influences sensitivity to FGFR kinase inhibitors
J. Wesche, M. Kostas, E. M. Haugsten, Y. Zhen, V. Sorensen, P. Szybowska, E. Fiorito, S. Lorenz, G. A. de Souza, A. Wiedlocha
The paper identifies PTPRG as a phosphatase that dephosphorylates FGFR1, enhancing FGFR inhibitor sensitivity in osteosarcoma cells.
bioRxiv · Mar 24, 2017Cell Biology