Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
J. J. W. Wong, S. Lorenz, P. K. Selbo
This study combines all-trans retinoic acid with photodynamic therapy to enhance anti-tumor effects in solid cancers, showing synergistic cytotoxicity and gene expression changes in colorectal cancer cells.
bioRxiv · Apr 28, 2022Cancer Biology
D. Rinchai, S. Deola, G. Zoppoli, B. S. A. Kabeer, S. A. Taleb, I. Pavlovski, S. Maacha, G. Gentilcore, M. Toufiq, L. Matthew, L. Liu, F. R. Vempalli, G. Mubarak, S. Lorenz, I. Sivieri, , D. Chaussabel
This study uses high-temporal-resolution transcriptome profiling to compare interferon responses after mRNA vaccination and SARS-CoV-2 infection, identifying distinct signatures linked to immune outcomes.
bioRxiv · Dec 12, 2021 · PreprintImmunology
E. Hoye, B. Fromm, P. H. M. Bottger, D. Domanska, A. T. Kristensen, C. Lund-Andersen, T. W. Abrahamsen, A. A. Fretland, V. J. Dagenborg, S. Lorenz, B. Edwin, E. Hovig, K. Flatmark
This study identifies a microRNA signature associated with metastatic progression in colorectal cancer using NGS data from 268 samples.
bioRxiv · Jun 1, 2020 · PreprintCancer Biology
A. Pfefferle, H. Netskar, E. H. Ask, S. Lorenz, J. P. Goodridge, E. Sohlberg, T. Clancy, K.-J. Malmberg
This study maps the transcriptional changes during human NK cell differentiation using single-cell RNA sequencing, identifying key gene programs and checkpoints.
bioRxiv · May 7, 2019 · PreprintImmunology
A. Pfefferle, B. Jacobs, E. H. Ask, S. Lorenz, T. Clancy, J. P. Goodridge, E. Sohlberg, K.-J. Malmberg
The paper uses flow cytometry and single-cell RNA sequencing to show intra-lineage plasticity and functional reprogramming maintain NK cell repertoire diversity during IL-15-driven homeostasis.
bioRxiv · Jan 9, 2019Immunology
B. Jacobs, A. Pfefferle, D. Clement, J. P. Goodridge, M. L. Saetersmoen, S. Lorenz, M. T. Wiiger, K.-J. Malmberg
The paper shows that IL-15 withdrawal induces apoptosis in NK cells by increasing BIM short splice variant expression, linked to caspase-3 activation and cell death.
bioRxiv · Aug 17, 2018Immunology
J. P. Goodridge, B. Jacobs, M. L. Satersmoen, D. Clement, T. Clancy, E. Skarpen, A. Brech, J. Landskron, C. Grimm, A. Pfefferle, L. Meza-Zepeda, S. Lorenz, M. T. Wiiger, W. E. Louch, E. H. Ask, , K.-J. Malmberg
This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.
bioRxiv · Jul 4, 2018Immunology
J. Wesche, M. Kostas, E. M. Haugsten, Y. Zhen, V. Sorensen, P. Szybowska, E. Fiorito, S. Lorenz, G. A. de Souza, A. Wiedlocha
The paper identifies PTPRG as a phosphatase that dephosphorylates FGFR1, enhancing FGFR inhibitor sensitivity in osteosarcoma cells.
bioRxiv · Mar 24, 2017Cell Biology